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Chronic psycho-social stress & colitis: Physiological, neuroendocrine, and immunological studies with male C57BL/6 mice

URN to cite this document:
urn:nbn:de:bvb:355-opus-7760
DOI to cite this document:
10.5283/epub.10558
Reber, Stefan Oskar
Date of publication of this fulltext: 04 Oct 2007 11:55


Abstract (German)

The experiments of the present thesis were designed to investigate the effects of two different models of chronic psycho-social stress (SD/OC; CSC) on the severity of and the regeneration after an experimentally induced colitis and the development of spontaneous colonic inflammation in male mice. In addition, underlying mechanisms were investigated, thereby mainly focusing on the HPA axis as a ...

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Translation of the abstract (German)

Das Ziel der vorliegenden Arbeit war es nun, an männlichen Mäusen (C57BL/6) den Einfluss von zwei unterschiedlichen chronischen psychosozialen Stressoren auf den Schweregrad und die Abheilung einer experimentell induzierten bzw. auf die Enstehung einer spontanen Darmentzündung zu untersuchen und die verantwortlichen Meachanismen offenzulegen. Das Hauptaugenmerk wird dabei auf die Involvierung von ...

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