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Potassium channels in prostate and colonic cancer

URN to cite this document:
urn:nbn:de:bvb:355-opus-8563
Ousingsawat, Jiraporn
Date of publication of this fulltext: 12 Oct 2007 12:09


Abstract (German)

Large conductance Ca2+-activated K+ channels in human prostate cancer The KCNMA1 gene encoding the alpha-subunit of BK channels is amplified and BK channel expression is enhanced in late-stage, metastatic and hormone-refractory human prostate cancer tissues, whereas benign prostate tissues show only a weak expression of BK channels. PC-3 hormone-insensitive prostate cancer cells, but not ...

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Translation of the abstract (German)

Ca2+- abhängige Kaliumkanäle (BK) in Prostatakarzinom KCNMA1 kodiert für die alpha-Untereinheit des großen Ca2+- abhängigen (BK) K+- Kanals und liegt in Spätstadien hormoninsensitive Prostatakarzinome in amplifizierter Form vor. Im Gegensatz hierzu zeigten gutartige Prostatagewebe eine nur schwache Expression von BK. Die Rolle von BK Kanälen für die Proliferation von Zellen des In PC-3 ...

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