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Identification of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gamma delta T cells in Escherichia coli

Hintz, M., Reichenberg, A., Altincicek, B., Bahr, U., Gschwind, R. M., Kollas, A., Beck, E., Wiesner, J., Eberl, M. and Jomaa, H. (2001) Identification of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gamma delta T cells in Escherichia coli. FEBS Letters 509 (2), pp. 317-322.

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Abstract

The gcpE and lytB gene products control the terminal steps of isoprenoid biosynthesis via the 2-C-methyl-Image -erythritol 4-phosphate pathway in Escherichia coli. In lytB-deficient mutants, a highly immunogenic compound accumulates significantly, compared to wild-type E. coli, but is apparently absent in gcpE-deficient mutants. Here, this compound was purified from E. coli ΔlytB mutants by ...

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Item type:Article
Date:2001
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Ruth Gschwind
Identification Number:
ValueType
10.1016/S0014-5793(01)03191-XDOI
Keywords:γδ T cell; 2-C-Methyl-Image -erythritol 4-phosphate pathway; 4-Hydroxy-3-methyl-but-2-enyl pyrophosphate; gcpE; lytB
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:10647
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