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Identification of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gamma delta T cells in Escherichia coli

Hintz, M. ; Reichenberg, A. ; Altincicek, B. ; Bahr, U. ; Gschwind, R. M. ; Kollas, A. ; Beck, E. ; Wiesner, J. ; Eberl, M. ; Jomaa, H.


The gcpE and lytB gene products control the terminal steps of isoprenoid biosynthesis via the 2-C-methyl-Image -erythritol 4-phosphate pathway in Escherichia coli. In lytB-deficient mutants, a highly immunogenic compound accumulates significantly, compared to wild-type E. coli, but is apparently absent in gcpE-deficient mutants. Here, this compound was purified from E. coli ΔlytB mutants by ...


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