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Hyphenated mass spectrometric methods for quantitative metabolomics in E. coli and human cells

Timischl, Birgit (2008) Hyphenated mass spectrometric methods for quantitative metabolomics in E. coli and human cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 26 Nov 2008 16:30

Abstract (English)

The combination of several different approaches is required for the comprehensive analysis of all the small molecules in a biological system, termed metabolomics. Here, we present two different strategies towards this final goal. A capillary electrophoresis - mass spectrometry method was developed and validated for the quantitative analysis of negatively charged metabolites by making use of the ...


Translation of the abstract (German)

Die umfassende Analyse aller kleinen Moleküle eines biologischen Systems, genannt Metabolomics, kann derzeit nur durch die Kombination von mehreren unterschiedlichen analytischen Methoden erfolgen. In der vorliegenden Arbeit werden zwei Strategien in diesem Kontext vorgestellt. Eine Methode basierend auf Kapillarelektrophorese � Massenspektrometrie wurde für die quantitative Analyse von ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:25 November 2008
Referee:Peter J. (Prof. Dr.) Oefner
Date of exam:8 September 2008
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis)
Keywords:GC-MS , HPLC-MS , Massenspektrometrie , Kapillarelektrophorese , Escherichia coli , Metabolom , Quantitative Analyse , Metabolomics , Flussanalyse , Ionenpaar-Flüssigkeitschromatographie , mass spectrometry , flux analysis , capillary electrophoresis , rapid resolution , ion-pair liquid chromatography
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10785
Owner only: item control page


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