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Induction of Raf kinase inhibitor protein contributes to macrophage differentiation

Schuierer, Marion M., Heilmeier, Ursula, Boettcher, Alfred, Ugocsai, Peter, Bosserhoff, Anja K., Schmitz, Gerd and Langmann, Thomas (2006) Induction of Raf kinase inhibitor protein contributes to macrophage differentiation. Biochemical and biophysical research communications 342 (4), pp. 1083-1087.

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Other URL: http://dx.doi.org/10.1016/j.bbrc.2006.02.083


Differential gene expression analysis of human blood monocytes has identified the Raf kinase inhibitor protein (RKIP) as a continuously upregulated gene in macrophage and dendritic cell maturation. Using realtime RT-PCR and Western blot analysis we were able to confirm the initial DNA-microarray findings of RKIP induction on mRNA and protein levels. RKIP upregulation in primary cells and ...


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Item type:Article
Date:21 April 2006
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Identification Number:
16513087PubMed ID
Keywords:Gene expression; Raf kinase inhibitor protein; Macrophage differentiation; NFκB; Scavenger receptors; THP-1 cells
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:1099
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