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Induction of Raf kinase inhibitor protein contributes to macrophage differentiation

DOI to cite this document:
Schuierer, Marion M. ; Heilmeier, Ursula ; Boettcher, Alfred ; Ugocsai, Peter ; Bosserhoff, Anja K. ; Schmitz, Gerd ; Langmann, Thomas
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Date of publication of this fulltext: 05 Aug 2009 13:25


Differential gene expression analysis of human blood monocytes has identified the Raf kinase inhibitor protein (RKIP) as a continuously upregulated gene in macrophage and dendritic cell maturation. Using realtime RT-PCR and Western blot analysis we were able to confirm the initial DNA-microarray findings of RKIP induction on mRNA and protein levels. RKIP upregulation in primary cells and ...


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