p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes

DOI to cite this document:: 10.5283/epub.1102

Radons, Jürgen ; Bosserhoff, Anja Katrin ; Grässel, Susanne ; Falk, Werner ; Schubert, Thomas E. O.

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Abstract

The pleiotropic cytokine interleukin 1 (IL-1) is considered to be the principal inducer of mediators of cartilage degradation in both, osteoarthritis (OA) and rheumatoid arthritis (RA). IL-1 activates numerous signaling pathways involved in cartilage destruction and dedifferentiation of chondrocytes. In this study, we analyzed expression and functional effects of IL-1 in human chondrocytes. We ...