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Fischer-344 rats are unsuitable for the MCAO filament model due to their cerebrovascular anatomy

Dittmar, Michael S. ; Vatankhah, Bijan ; Fehm, Nando P. ; Schuierer, Gerhard ; Bogdahn, Ulrich ; Horn, Markus ; Schlachetzki, Felix
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Date of publication of this fulltext: 05 Aug 2009 13:25


Abstract

Middle cerebral artery occlusion (MCAO) in Fischer-344 rats results in a small variance of infarct size. However, complications are frequent especially in aged Fisher-344 rats undergoing endovascular suture occlusion of the middle cerebral artery. Analyzing our experiences with 165 Wistar, 13 Sprague-Dawley and 10 F-344 rats, we compared the incidence of impossible thread advancement and ...

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