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Studies on the non-mevalonate isoprenoid biosynthetic pathway. Simple methods for preparation of isotope-labeled (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate

Hecht, S., Amslinger, S., Jauch, J., Kis, K., Trentinaglia, V., Adam, P., Eisenreich, W., Bacher, A. and Rohdich, F. (2002) Studies on the non-mevalonate isoprenoid biosynthetic pathway. Simple methods for preparation of isotope-labeled (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate. Tetrahedron Lett. 43 (49), pp. 8929-8933.

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Abstract

(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-H-3]-6 and [1-H-2(1)]-6 from the same starting material in four steps where the hydrogen isotope is ...

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Item type:Article
Date:2002
Additional Information (public):Times Cited: 10
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
ISI:000179238400030Web of Science ID
10.1016/S0040-4039(02)02195-0DOI
Keywords:Escherichia-coli precursor thiamin d-1-deoxyxylulose 5-phosphate pyridoxol thiazole
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:11073
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