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Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor

DOI to cite this document:
Gamulescu, Maria-Andreea ; Chen, Youxin ; He, Shikun ; Spee, Christine ; Jin, Manlin ; Ryan, Stephen J. ; Hinton, David R.
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Date of publication of this fulltext: 05 Aug 2009 13:25


Retinal pigment epithelial (RPE) cells possess the potential to transdifferentiate into myofibroblasts after stimulation with transforming growth factor beta (TGFbeta) and are implicated in the pathogenesis of proliferative vitreoretinopathy. In this study we evaluated how TGFbeta2 and various extracellular matrix (ECM) proteins modulate the transdifferentiation of human fetal retinal pigment ...


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