Expression of tumor necrosis factor alpha and its receptors during cellular differentiation

DOI to cite this document:: 10.5283/epub.1206

Schling, Petra ; Rudolph, Christian ; Heimerl, Susanne ; Fruth, Sabine ; Schmitz, Gerd

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Abstract

Tumor necrosis factor alpha (TNFalpha) is a potent proinflammatory cytokine also involved in cellular differentiation processes. TNFalpha and both of its receptors (TNFR1 and TNFR2) can be co-expressed on the same cell, allowing for local signaling. This study has examined the expression of all components necessary for autocrine cytokine regulation during human hematopoietic, epithelial, and ...