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Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro

Kunz-Schughart, Leoni A. ; Schroeder, Josef A. ; Wondrak, Marit ; Rey, Frank van ; Lehle, Karla ; Hofstaedter, Ferdinand ; Wheatley, Denys N.
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Date of publication of this fulltext: 05 Aug 2009 13:25


Abstract

The development of vessel-like structures in vitro to mimic as well as to realize the possibility of tissue-engineered small vascular networks presents a major challenge to cell biologists and biotechnologists. We aimed to establish a three-dimensional (3-D) culture system with an endothelial network that does not require artificial substrates or ECM compounds. By using human skin fibroblasts and ...

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