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Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro

Kunz-Schughart, Leoni A., Schroeder, Josef A., Wondrak, Marit, Rey, Frank van, Lehle, Karla, Hofstaedter, Ferdinand and Wheatley, Denys N. (2006) Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. American journal of physiology. Cell physiology 290 (5), C1385-C1398.

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Date of publication of this fulltext: 05 Aug 2009 13:25

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Other URL: http://dx.doi.org/10.1152/ajpcell.00248.2005


Abstract

The development of vessel-like structures in vitro to mimic as well as to realize the possibility of tissue-engineered small vascular networks presents a major challenge to cell biologists and biotechnologists. We aimed to establish a three-dimensional (3-D) culture system with an endothelial network that does not require artificial substrates or ECM compounds. By using human skin fibroblasts and ...

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Item type:Article
Date:May 2006
Institutions:Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie
Identification Number:
ValueType
10.1152/ajpcell.00248.2005DOI
16601149PubMed ID
Keywords:endothelium; angiogenesis; human umbilical vein endothelial cell; multicellular spheroid; coculture; tubular structures
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:1211
Owner only: item control page

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