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Design, synthesis and structural evaluation of peptidomimetics with a defined secondary structure

Delatouche, Régis (2009) Design, synthesis and structural evaluation of peptidomimetics with a defined secondary structure. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Jan 2010 15:25

Abstract (English)

The synthesis of new delta-amino acids based on a gamma-butyrolactone ring was performed and they were inserted into various peptidomimetics for conformational studies. Some non-substituted and substituted butyrolactone building blocks were prepared by various methods. Then, homopeptides as well as mixed peptides were prepared and their secondary structures analysed by various techniques ...


Translation of the abstract (German)

Durchgeführt wurde die Synthese von neuen, auf einen gamma-Butyrolaktonring basierenden, delta-Aminosäuren und deren Einbau in verschiedene Peptidomimetika für Konformationstudien. Einige unsubstituierte sowie funktionalisierte gamma-Butyrolakton Einheiten wurden dargestellt. Anschließend wurden Homo-Peptide und gemischte Peptide dargestellt und deren Sekundärstruktur durch verschiedene ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:6 December 2009
Referee:Oliver (Prof. Dr.) Reiser
Date of exam:3 December 2008
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:Peptide , Peptidsynthese , Peptid-Bindung , Synthetische Peptide , Cyclopeptide , Piperazindion <2,5-> , Peptidomimetikum , Molekulardesign , , delta amino acid , diketopiperazine , peptidomimetics , unnatural amino acid , secondary structure , gamma butyrolactone
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12139
Owner only: item control page


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