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Design, synthesis and structural evaluation of peptidomimetics with a defined secondary structure

URN to cite this document:
urn:nbn:de:bvb:355-opus-11050
Delatouche, Régis
Date of publication of this fulltext: 14 Jan 2010 15:25


Abstract (English)

The synthesis of new delta-amino acids based on a gamma-butyrolactone ring was performed and they were inserted into various peptidomimetics for conformational studies. Some non-substituted and substituted butyrolactone building blocks were prepared by various methods. Then, homopeptides as well as mixed peptides were prepared and their secondary structures analysed by various techniques ...

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Translation of the abstract (German)

Durchgeführt wurde die Synthese von neuen, auf einen gamma-Butyrolaktonring basierenden, delta-Aminosäuren und deren Einbau in verschiedene Peptidomimetika für Konformationstudien. Einige unsubstituierte sowie funktionalisierte gamma-Butyrolakton Einheiten wurden dargestellt. Anschließend wurden Homo-Peptide und gemischte Peptide dargestellt und deren Sekundärstruktur durch verschiedene ...

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