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Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors

Wild, Peter J. ; Meyer, Stefanie ; Bataille, Frauke ; Woenckhaus, Matthias ; Ameres, Markus ; Vogt, Thomas ; Landthaler, Michael ; Pauer, Armin ; Klinkhammer-Schalke, Monika ; Hofstaedter, Ferdinand ; Bosserhoff, Anja K.
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

BACKGROUND: Using tissue microarrays, we investigated whether methylthioadenosine phosphorylase (MTAP) protein expression is associated with clinicopathologic variables in benign and malignant melanocytic skin tumors. OBSERVATIONS: Cytoplasmic MTAP expression was detected in 227 (72.1%) of 315 informative cases. Expression was significantly reduced in primary malignant melanomas and in melanoma ...

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