DX5+ NKT cells induce the death of colitis-associated cells: involvement of programmed death ligand-1

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1220

Hornung, Matthias ; Farkas, Stefan A. ; Sattler, Christine ; Schlitt, Hans J. ; Geissler, Edward K.

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:26

Alternative Links zum Volltext:DOI Pubmed Verlag

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Zusammenfassung

NKT cells are activated by CD1d and show an immune regulating function. Here, we investigated whether DX5+ NKT cells could be used to reduce colitis in a chronic colitis mouse model and studied the potential immunological mechanisms involved. Chronic colitis was induced either by transfer of enriched CD62L+ CD4+ T cells to severe-combined-immunodeficient mice or by feeding dextran sodium sulfate ...