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SCF modulates organ distribution and hematopoietic engraftment of CB-derived pluripotent HPC transplanted in NOD/SCID mice

Drewel, D. ; Luecke, K. ; Mueller, G. ; Kunz-Schughart, L. A. ; Dietl, B. ; Zeitler, I. ; Andreesen, Reinhard ; Hennemann, B.



Abstract

BACKGROUND: During the engraftment process of transplanted HPC, the beta 1 integrins play an important role. An increased expression and adhesive function of these integrins has been shown in hematopoietic cell lines and peripheral blood-derived HPC after stimulation with SCF. In this study, we investigated the influence of SCF on the engraftment capability and tissue distribution of cord blood ...

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