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Differentiation of hematopoietic progenitor cells towards the myeloid and B-lymphoid lineage by hepatocyte growth factor (HGF) and thrombopoietin (TPO) together with early acting cytokines

DOI to cite this document:
10.5283/epub.1230
Grassinger, Jochen ; Mueller, Gunnar ; Zaiss, Matthias ; Kunz-Schughart, Leoni A. ; Andreesen, Reinhard ; Hennemann, Burkhard
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

Objectives: The effect of stem cell factor (SCF), flt3-ligand (FL), and interleukin (IL)-3 (SF3) in combination with hepatocyte growth factor (HGF), thrombopoietin (TPO), and Hyper-IL-6 on maintenance and differentiation of early human peripheral blood-derived progenitor cells was investigated. Methods: Single sorted CD34(+) 38(-) cells were cultured with various combinations of these growth ...

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