Differentiation of hematopoietic progenitor cells towards the myeloid and B-lymphoid lineage by hepatocyte growth factor (HGF) and thrombopoietin (TPO) together with early acting cytokines

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1230

Grassinger, Jochen ; Mueller, Gunnar ; Zaiss, Matthias ; Kunz-Schughart, Leoni A. ; Andreesen, Reinhard ; Hennemann, Burkhard

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:26

Alternative Links zum Volltext:Pubmed DOI Verlag

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Objectives: The effect of stem cell factor (SCF), flt3-ligand (FL), and interleukin (IL)-3 (SF3) in combination with hepatocyte growth factor (HGF), thrombopoietin (TPO), and Hyper-IL-6 on maintenance and differentiation of early human peripheral blood-derived progenitor cells was investigated. Methods: Single sorted CD34(+) 38(-) cells were cultured with various combinations of these growth ...