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Hypoxia inducible factor 1 (HIF 1) alpha- und beta-vermittelte Induktion der ABCA1-Promotor-Aktivität

URN to cite this document:
urn:nbn:de:bvb:355-opus-13062
Hohenstatt, Antonia
Date of publication of this fulltext: 11 Aug 2009 14:09


Abstract (German)

Im Rahmen dieser Untersuchung sollte die transkriptionelle Regulation des ABCA1-Promotors durch den Transkriptionsfaktor HIF1 in den für den Lipidstoffwechsel relevanten Zellen HepG2 und RAW 264.7 nachgewiesen werden. Mittels DNA-Mikroarrays konnte bereits eine ABCA1-Regulation unter hypoxischen Bedingungen und durch Überexpression einer konstitutiv aktiven Form von HIF1 alpha; in menschlichen ...

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Translation of the abstract (English)

ABCA1 is one of the major regulators of hepatic and peripheral cholesterol metabolism. Changes in ABCA1 expression greatly influence cholesterol production in the liver and reverse cholesterol transport from peripheral tissues back to the liver, which is closely related to manifestation of atherosclerosis. Atherosclerotic lesion associated local as well as systemic hypoxia adversely affects ...

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