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Photodynamic therapy with 5-aminolevulinic acid induces distinct microcirculatory effects following systemic or topical application

Schacht, Vivien ; Szeimies, Rolf-Markus ; Abels, Christoph



Abstract

In photodynamic therapy (PDT) the photosensitiser 5-aminolaevulinic acid (ALA) can be used by systemic or topical application. Previous experiments showed that the photodynamic effects might not be mediated solely by porphyrins localized in the parenchyma, but also by porphyrins in the microvasculature. Therefore, the microcirculatory effects of PDT following systemic versus topical application ...

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