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Effective silencing of EGFR with RNAi demonstrates non-EGFR dependent proliferation of glioma cells

Vollmann, Arabel ; Vornlocher, Hans-Peter ; Stempfl, Thomas ; Brockhoff, Gero ; Apfel, Rainer ; Bogdahn, Ulrich
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

The epidermal growth factor receptor (EGFR, ErbB1) is frequently dysregulated in a variety of solid human tumors, including malignant glioma. EGFR expression has been associated with disease progression, resistance to standard therapies and poor survival. The application of small interfering RNAs (siRNAs) has become an effective and highly specific tool to modulate gene expression, and a wide ...

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