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Das Kalzium-Paradoxon der Reninsekretion: Rolle kalziumregulierter Adenylatzyklasen

Grünberger, Christian (2009) Das Kalzium-Paradoxon der Reninsekretion: Rolle kalziumregulierter Adenylatzyklasen. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Jan 2010 14:11

Abstract (German)

Ein Anstieg der freien intrazellulären Kalziumkonzentration fördert den Exozytosevorgang in den meisten sekretorisch aktiven Zellen. Im Gegensatz dazu wird die Reninfreisetzung aus Juxtaglomerulären (JG) Zellen durch Kalzium gehemmt. Die genauen nachgeordneten intrazellulären Signalkaskaden dieses so genannten �Kalzium-Paradoxon� der Reninsekretion waren bisher komplett ungeklärt. Da cAMP den ...

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Translation of the abstract (English)

An increase in the free intracellular calcium concentration promotes exocytosis in most secretory cells. In contrast, renin release from juxtaglomerular (JG) cells is suppressed by calcium. The further downstream signaling cascades of this so called �calcium paradoxon� of renin secretion have been incompletely defined. Because cAMP is the main intracellular stimulator of renin release, we ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:29 October 2009
Referee:Frank (Prof. Dr.) Schweda
Date of exam:20 October 2009
Additional Information (public):Circulation Research 2006 Nov 24;99(11):1197-1206 ; ISSN 1524-4571
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda
Keywords:Renin , Renin-Angiotensin-System , Adenylatcyclase , Cyclo-AMP , Sekretion , Juxtaglomerulärer Apparat , Calcium , Angiotensin II , Endothelin , Juxtaglomeruläre Zelle , Isoproterenol , cAMP , Kalzium-Paradoxon , juxtaglomerular cell , isoproterenol , cAMP , calcium paradoxon
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12353
Owner only: item control page

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