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Analysis of the effects of xanthohumol on hepatic homeostasis, inflammation, fibrosis and cancerogenesis

Dorn, Christoph Michael (2009) Analysis of the effects of xanthohumol on hepatic homeostasis, inflammation, fibrosis and cancerogenesis. PhD, Universität Regensburg.

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Date of publication of this fulltext: 18 Jan 2010 14:11

Abstract (English)

Xanthohumol is the major prenylated chalcone found in hops, and it has been shown to exhibit various biological effects. However, xanthohumol effects on liver cells or in liver diseases, respectively, are widely unknown. In the present work, first the effects of xanthohumol on hepatic stellate cells (HSC), the central mediators of liver fibrogenesis, were analyzed. Xanthohumol inhibited the ...

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Translation of the abstract (German)

Für Xanthohumol, ein im Hopfen vorkommendes prenyliertes Chalcon, konnte eine Vielzahl von biologischen Effekten nachgewiesen werden. Wirkungen von Xanthohumol auf Leberzellen oder bei Lebererkrankungen sind jedoch weitgehend unbekannt. In dieser Arbeit wurden zunächst Effekte von Xanthohumol auf hepatische Sternzellen (HSC), den zentralen Mediatoren der Leberfibrogenese, analysiert. Xanthohumol ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:9 November 2009
Referee:Jörg (Prof. Dr.) Heilmann
Date of exam:12 October 2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Keywords:Xanthohumol , Flavonoide , Leberfibrose , Leberzellkrebs , Nichtalkoholische Fettleberhepatitis , Kupffer-Sternzelle , Carcinogenese , Entzündung , , xanthohumol , prenylflavonoid , liver fibrosis , hepatocellular carcinoma , NASH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12363
Owner only: item control page

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