Soluble galectin-3 is a strong, colonic epithelial-cell-derived, lamina propria fibroblast-stimulating factor

DOI to cite this document:: 10.5283/epub.1240

Lippert, E. ; Falk, W. ; Bataille, F. ; Kaehne, T. ; Naumann, M.

; Goeke, M. ; Herfarth, H. ; Schoelmerich, J. ; Rogler, G.

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Abstract

Background: Colonic lamina propria fibroblasts (CLPFs) play an important role in the pathogenesis of fibrosis and strictures in Crohn's disease. Aim: To identify colonic epithelial cell (CEC)-derived factors that activate CLPFs. Methods: Primary human CECs and CLPFs were isolated from control mucosa and interleukin 8 (IL8) of CLPF cultures was quantified by ELISA. Activation of nuclear factor ...