Die unterschiedlichen Migrationspotentiale von Myofibroblasten aus entzündeter, fistulierter und stenosierter Darmschleimhaut von Morbus-Crohn-Patienten gehen mit einer unterschiedlichen Expression der Focal Adhesion Kinase (FAK) einher

URN to cite this document:: urn:nbn:de:bvb:355-epub-124128
DOI to cite this document:: 10.5283/epub.12412

Meier, Johannes

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Date of publication of this fulltext: 18 Feb 2010 14:24

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Item type:	Thesis of the University of Regensburg (PhD)
Date:	18 February 2010
Referee:	Prof. Dr. Dr. Gerhard Rogler and Prof. Dr. Dr. Torsten E. Reichert
Date of exam:	21 January 2010
Institutions:	Medicine > Lehrstuhl für Innere Medizin I
Keywords:	Crohn’s disease, fibrosis, strictures, myofibroblasts, migration, wound healing, focal adhesion kinase
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	12412

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Abstract (German)

Im 3D-Matrixmodell konnte gezeigt werden, dass sich Myofibroblasten aus entzündeter, fistulierter und stenosierter Darmschleimhaut von Morbus Crohn Patienten hinsichtlich Ihrer Migrationspotentiale voneinander unterscheiden. Dies geht ausserdem mit einer unterschiedlichen Expression der Focal Adhesion Kinase (FAK) einher.

Translation of the abstract (English)

Myofibroblasts isolated from inflamed, fibrostenotic or fistulized CD mucosa differ in their migratory potential both in the modified Boyden chamber as well as in a 3D-matrix model. These different migratory behaviours are associated with a different expression of FAK.

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