(E)-metanicotine hemigalactarate (TC-2403-12) inhibits IL-8 production in cells of the inflamed mucosa

DOI to cite this document:: 10.5283/epub.1243

Spoettl, Tanja ; Paetzel, Christine ; Herfarth, Hans ; Bencherif, Merouane ; Schoelmerich, Juergen ; Greinwald, Roland ; Gatto, Gregory J. ; Rogler, Gerhard

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Abstract

BACKGROUND: Nicotine is of therapeutic value in ulcerative colitis, but its administration is connected with adverse events. Nicotine derivatives are currently being tested to maintain the therapeutic effects and minimize adverse events. TC-2403-12 is a (E)-metanicotine hemigalactarate. The aim of this study was to determine the effectiveness of TC-2403-12 in the inhibition of TNF- and ...