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Antibiotic-induced prolonged cholestasis: suspected induction by ceftibuten

Combe, C. ; Banas, B. ; Zoller, W. G. ; Manns, M. P. ; Schlöndorff, D.


We report on a 43-year-old female diabetic patient who was treated with ceftibuten because of Pseudomonas aeruginosa induced otitis externa. Thereafter she developed a prolonged seven-months-persisting irreversible cholestasis. Liver puncutre revealed a canalicular and hepatocellular cholestasis without liver cell necrosis or bile duct injury. After seven-months the patient died because of antibiotic-resistant Pseudomonas-septicemia.

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