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Expression of chemokines and their receptors in nephrotoxic serum nephritis

Schadde, E. ; Kretzler, M. ; Banas, B. ; Luckow, B. ; Assmann, K. ; Schlöndorff, D.
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

BACKGROUND: Chemokines play a major role in leukocyte infiltration in inflammatory kidney diseases. The specificity of the chemokine action is determined by the restricted expression of the corresponding receptors on leukocytes. We therefore simultaneously studied the expression of CC-chemokine and CC-chemokine receptor 1-5 (CCR 1-5) mRNA in an accelerated model of nephrotoxic nephritis in CD-1 ...

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