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Modulation of HIV-1 enhancer activity and virus production by cAMP

DOI to cite this document:
Banas, B. ; Eberle, J. ; Banas, B. ; Schlöndorff, D. ; Luckow, B.
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Date of publication of this fulltext: 05 Aug 2009 13:26


The effect of cAMP on the transcriptional activity of the HIV-1 long terminal repeat/enhancer was investigated and compared to the effect of cAMP on virus replication. In culture cAMP repressed virus replication in vivo using different cell types. Transient transfection studies with HIV-1 enhancer-derived luciferase reporter gene constructs identified the minimal DNA sequence mediating the ...


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