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Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis

Banas, Bernhard ; Wörnle, Markus ; Berger, Thorsten ; Nelson, Peter J. ; Cohen, Clemens D. ; Kretzler, Matthias ; Pfirstinger, Jochen ; Mack, Matthias ; Lipp, Martin ; Gröne, Hermann-Josef ; Schlöndorff, Detlef
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

The release of chemokines by intrinsic renal cells is an important mechanism for the regulation of leukocyte trafficking during renal inflammation. The expression of chemokine receptors by intrinsic renal cells such as mesangial cells (MC) suggests an expanded role for chemokine-chemokine receptor biology in local immunomodulation and potentially glomerular homeostasis. By immunohistochemistry we ...

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