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Protein kinase C (PKC) dependent induction of tissue factor (TF) by mesangial cells in response to inflammatory mediators and release during apoptosis

Lang, Detlef ; Terstesse, Martin ; Dohle, Frank ; Bangen, Philip ; Banas, Bernhard ; Pauels, Hans-Gerd ; Heidenreich, Stefan
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

1. In inflammatory kidney diseases procoagulatory activity (PCA) becomes evident. Glomerular fibrin deposits and capillary microthrombi are histopathological hallmarks in most forms of glomerulonephritis. 2. Therefore in this study the expression of tissue factor (TF) as the main inducer of thrombogenesis was examined in cultured human mesangial cells (MC) in response to proinflammatory stimuli ...

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