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Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors

Anders, Hans-Joachim ; Banas, Bernhard ; Linde, Yvonne ; Weller, Lars ; Cohen, Clemens D ; Kretzler, Matthias ; Martin, Stefan ; Vielhauer, Volker ; Schlöndorff, Detlef ; Gröne, Hermann-Josef
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Date of publication of this fulltext: 05 Aug 2009 13:26


Abstract

Immune complex glomerulonephritis (GN) often deteriorates during infection with viruses and bacteria that, in contrast to mammals, have DNA that contains many unmethylated CpG motifs. Balb/c mice with horse apoferritin-induced GN (HAF-GN) were treated with either saline, CpG-oligodeoxynucleotides (ODN), or control GpC-ODN. Only CpG-ODN exacerbated HAF-GN with an increase of glomerular ...

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