CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration

DOI to cite this document:: 10.5283/epub.1272

Anders, Hans-Joachim ; Frink, Michael ; Linde, Yvonne ; Banas, Bernhard ; Wörnle, Markus ; Cohen, Clemens D. ; Vielhauer, Volker ; Nelson, Peter J. ; Gröne, Hermann-Josef ; Schlöndorff, Detlef

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Abstract

The chemokine CC chemokine ligand (CCL)5/RANTES as well as its respective receptor CCR5 mediate leukocyte infiltration during inflammation and are up-regulated early during the course of glomerulonephritis (GN). We tested the effects of the two CCL5/RANTES blocking analogs, Met-RANTES and amino-oxypentane-RANTES, on the course of horse apoferritin (HAF)-induced GN. HAF-injected control mice had ...