Alkylphosphocholines inhibit proliferation of human retinal pigment epithelial cells

DOI to cite this document:: 10.5283/epub.1274

Eibl, Kirsten H. ; Banas, Bernhard ; Schoenfeld, Carlo-L. ; May, Christian A. ; Neubauer, Aljoscha S. ; Priglinger, Siegfried ; Kampik, Anselm ; Welge-Lussen, Ulrich

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Abstract

PURPOSE: To investigate the effect and mechanism of action of alkylphosphocholines (APCs) on proliferation of human retinal pigment epithelium (RPE) cells and RPE-mediated collagen matrix contraction in vitro. METHODS: Cultured RPE cells of five human donors were treated with four APCs in the presence of fetal calf serum. Proliferation was assessed by the tetrazolium dye-reduction (MTT) assay and ...