Angiotensin inhibition reduces glomerular damage and renal chemokine expression in MRL/lpr mice

DOI to cite this document:: 10.5283/epub.1276

Perez de Lema, Guillermo ; de Wit, Cor ; Cohen, Clemens D. ; Nieto, Elena ; Molina, Ana ; Banas, Bernhard ; Luckow, Bruno ; Vicente, Ana B. ; Mampaso, Francisco ; Schlöndorff, Detlef

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Abstract

Beneficial effects of angiotensin II inhibition during inflammatory renal disease may involve both hemodynamic and nonhemodynamic mechanisms. To analyze whether angiotensin II inhibition has protective effects on lupus-like, autoimmune-mediated renal damage in MRL/lpr mice, four groups of mice were treated orally for 6 weeks with: 1) vehicle, 2) enalapril (3.0 mg/kg per day), 3) candesartan ...