Growth arrest specific protein 6/Axl signaling in human inflammatory renal diseases

DOI to cite this document:: 10.5283/epub.1280

Fiebeler, Anette ; Park, Joon-Keun ; Muller, Dominik N.

; Lindschau, Carsten

; Mengel, Michael ; Merkel, Saskia ; Banas, Bernhard ; Luft, Friedrich C.

; Haller, Hermann

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Date of publication of this fulltext: 05 Aug 2009 13:26

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Abstract

Background: Growth arrest-specific gene 6 (Gas6) and its binding partner, the receptor tyrosine kinase AxI, are important mediators in experimental nephritis. The authors tested whether the Gas6/Ax1 signaling pathway participates in human renal diseases. Methods: The authors compared 26 human renal specimens from patients with IgA nephritis, acute diffuse immune complex glomerulonephritis, acute ...