N-acetylcysteine in the prevention of radiocontrast-induced nephropathy: clinical trials and end points

DOI to cite this document:: 10.5283/epub.1285

Hoffmann, Ute ; Banas, Bernhard ; Fischereder, Michael ; Krämer, Bernhard K.

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Date of publication of this fulltext: 05 Aug 2009 13:27

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Abstract

N-acetylcysteine (NAC) has been suggested to prevent radiocontrast-induced nephropathy (RCIN) in patients with a reduced renal function. However, clinical studies have not been demonstrating this effect consistently. Also, reviews and meta-analyses dealing with the question of prevention of RCIN by NAC have been controversial. Nearly all investigators used serum creatinine as surrogate end point ...