Effects of chemokines on proliferation and apoptosis of human mesangial cells

DOI to cite this document:: 10.5283/epub.1286

Wörnle, Markus ; Schmid, Holger ; Merkle, Monika ; Banas, Bernhard

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Date of publication of this fulltext: 05 Aug 2009 13:27

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Abstract

BACKGROUND: Proliferation and apoptosis of mesangial cells (MC) are important mechanisms during nephrogenesis, for the maintenance of glomerular homeostasis as well as in renal disease and glomerular regeneration. Expression of chemokines and chemokine receptors by intrinsic renal cells, e.g. SLC/CCL21 on podocytes and CCR7 on MC is suggested to play a pivotal role during these processes. ...