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Enhanced ecto-apyrase activity of stimulated endothelial or mesangial cells is downregulated by glucocorticoids in vitro

Kapojos, Jola J. ; van den Berg, Anke ; Borghuis, Theo ; Banas, Bernhard ; Huitema, Sippie ; Poelstra, Klaas ; Bakker, Winston W.
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Date of publication of this fulltext: 05 Aug 2009 13:27


Abstract

Endothelial as well as mesangial cells show enhanced activity of ecto-apyrase following pro-inflammatory stimulation in vitro. Since this ecto-enzyme appears to be able to regulate plasma hemopexin, which latter molecule plays a role in the pathogenesis of corticosteroid responsive nephrotic syndrome, the question was raised whether glucocorticoids are potentially able to downregulate ...

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