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Binding of the chemokine SLC/CCL21 to its receptor CCR7 increases adhesive properties of human mesangial cells

Banas, Bernhard ; Wörnle, Markus ; Merkle, Monika ; Gonzalez-Rubio, Mercedes ; Schmid, Holger ; Kretzler, Matthias ; Pietrzyk, Miriam C. ; Fink, Monika ; Perez de Lema, Guillermo ; Schlöndorff, Detlef
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Date of publication of this fulltext: 05 Aug 2009 13:27


BACKGROUND: Adherence of human mesangial cells to the surrounding matrix contributes to glomerular homeostasis and is important for the maintenance of glomerular architecture and function in normal adult human kidney. The expression of chemokines and corresponding chemokine receptors on adjacent intrinsic renal cells indicates a novel chemokine/chemokine receptor function on nonimmune cells ...


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