Effects of mycophenolate mofetil on donor-specific antibody formation in renal transplantation

DOI to cite this document:: 10.5283/epub.1299

Lederer, Stephan R. ; Friedrich, Nicole ; Banas, Bernhard ; Welser, Georg ; Albert, Ekkehard D. ; Sitter, Thomas

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Date of publication of this fulltext: 05 Aug 2009 13:27

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Abstract

BACKGROUND: Mycophenolate mofetil (MMF) is a routinely used immunosuppressive agent that selectively blocks T- and B-lymphocyte proliferation. The present study was designed to investigate the effects of this drug on human leukocyte(HLA) antibody production in general and donor-specific antibody (DSA) formation in particular in 154 recipients of renal allografts. PATIENTS AND METHODS: Renal ...