TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells

DOI to cite this document:: 10.5283/epub.1315

Rodríguez-Barbero, A.

; Dorado, F. ; Velasco, S. ; Pandiella, A.

; Banas, B. ; López-Novoa, J. M.

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Date of publication of this fulltext: 05 Aug 2009 13:27

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Abstract

Transforming growth factor-beta 1 (TGF-beta 1) plays a fundamental role in the progression of renal diseases. Accumulating evidence has suggested that eicosanoids derived from cyclooxygenase-2 (COX-2) participate in a number of pathological processes in immune-mediated renal diseases. Mesangial cells (MC) play a major role in physiological and pathophysiological renal processes. MC express ...