Reverse diastolic intrarenal flow due to calcineurin inhibitor (CNI) toxicity

DOI to cite this document:: 10.5283/epub.1316

Böger, Carsten A. ; Rümmele, Petra ; Mihatsch, Michael J. ; Banas, Bernhard ; Krämer, Bernhard K.

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Date of publication of this fulltext: 05 Aug 2009 13:27

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Abstract

Renal calcineurin inhibitor (CNI) toxicity is a frequent side effect of immunosuppression with CNIs in solid organ transplantation, leading to acute and chronic renal failure. Acute CNI toxicity is due to vasoconstriction of the vasa afferens and efferens and vacuolization of smooth muscle cells with medial hyalinosis, leading to vessel lumen narrowing. Our case had an acute renal failure 8 ...