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Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene

Castrop, H. ; Oppermann, M. ; Weiss, Y. ; Huang, Y. ; Mizel, D. ; Lu, H. ; Germain, S. ; Schweda, F. ; Theilig, F. ; Bachmann, S. ; Briggs, J. ; Kurtz, A. ; Schnermann, J.



Abstract

To assess the feasibility of using the renin promoter for expressing Cre recombinase in juxtaglomerular (JG) cells only, we generated five independent transgenic mouse lines (designated hRen-Cre) expressing Cre recombinase under control of a 12.2-kb human renin promoter. In the kidneys of adult mice Cre mRNA (RT-PCR) was found in the renal cortex, with Cre protein (immunohistochemistry) being ...

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