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Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney

Banas, Miriam C. ; Parks, W. Tony ; Hudkins, Kelly L. ; Banas, Bernhard ; Holdren, Matthew ; Iyoda, Masayuki ; Wietecha, Tomasz A. ; Kowalewska, Jolanta ; Liu, Gang ; Alpers, Charles E.
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Date of publication of this fulltext: 05 Aug 2009 13:27


Abstract

Smad proteins are signaling intermediates of the TGF-beta superfamily and are involved in a range of biological activities including development and immune responses. We studied the expression of TGF-beta-receptor activated Smads (Smad2 and Smad3), the common partner Smad (Smad4), an inhibitory Smad (Smad7), and the activated (phosphorylated) Smad2 (pSmad2) in developing and adult kidneys of ...

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