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Anthraniloyl-derived nucleotides as potent and selective adenylyl cyclase inhibitors

Geduhn, Jens (2010) Anthraniloyl-derived nucleotides as potent and selective adenylyl cyclase inhibitors. PhD, Universität Regensburg.

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Date of publication of this fulltext: 22 Jun 2010 13:09

Abstract (English)

Mammals express nine membranous adenylyl cyclases (AC 1-9) for the catalysis of the important second messenger cAMP in the intracellular signaling pathway. Inhibitors of AC1 and AC5 may be useful drugs for neuroprotection, heart failure and longevity. 2�,3�-O-(N-Methylanthraniloyl) (MANT)-substituted nucleotides are competitive AC inhibitors and were synthesized with different nucleobases in high ...


Translation of the abstract (German)

Säugetiere exprimieren neun membranäre Adenylyl-Zyklasen (AC 1-9) für die Katalyse des wichtigen second messengers cAMP in der intrazelluären Signaltransduktion. Inhibitoren von AC1 und AC5 könnten nützliche Arzneistoffe für Neuroprotektion, Herzinsuffizienz und eine verlängerte Lebenserwartung darstellen. 2�,3�-O-(N-Methylanthraniloyl) (MANT)-substituierte Nukleotide sind kompetitive ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:22 June 2010
Referee:Prof. Dr. Burkhard König
Date of exam:30 April 2009
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:Nukleotide, Adenylyl-Zyklase, Inhibitor, MANT, Nukleotide, CyaA, adenylyl cyclase, inhibitor, MANT, nucleotide, CyaA
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13416
Owner only: item control page


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