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Regulation of type 1 fimbriae synthesis and biofilm formation by the transcriptional regulator LrhA of Escherichia coli

Blumer, Caroline ; Kleefeld, Alexandra ; Lehnen, Daniela ; Heintz, Margit ; Dobrindt, Ulrich ; Nagy, Gábor ; Michaelis, Kai ; Emödy, Levente ; Polen, Tino ; Rachel, Reinhard ; Wendisch, Volker F. ; Unden, Gottfried



Abstract

Type 1 fimbriae of Escherichia coli facilitate attachment to the host mucosa and promote biofilm formation on abiotic surfaces. The transcriptional regulator LrhA, which is known as a repressor of flagellar, motility and chemotaxis genes, regulates biofilm formation and expression of type 1 fimbriae. Whole-genome expression profiling revealed that inactivation of lrhA results in an increased ...

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