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Rolle der cAMP-Zielsequenzen in der Regulation des humanen Reningens in vitro und in vivo

Desch, Michael (2010) Rolle der cAMP-Zielsequenzen in der Regulation des humanen Reningens in vitro und in vivo. PhD, Universität Regensburg.

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Date of publication of this fulltext: 17 Jan 2011 15:01

Abstract (German)

Ein funktionelles systemisches Renin-Angiotensin-System (RAS) ist für die Regulation des Blutdruckes und des Salz- und Wasserhaushaltes essentiell. Gravierende Änderungen in diesem System können zu verschiedenen kardiovaskulären Krankheiten, wie Bluthochdruck und Herzinsuffizienz und auch zu Nierenkrankheiten führen. Die Protease Renin stellt den limitierenden Faktor im RAS dar. Plasma-Renin wird ...

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Translation of the abstract (English)

Renin plays central role in the regulation of blood pressure by catalyzing the limiting step in the generation of angiotensin II. The cAMP/PKA cascade is believed to be the central intracellular mechanism that controls the expression of renin. Two cAMP target sequences were identified in the human renin gene: a consensus cAMP Response Element (CRE) in the distal enhancer and a non-canonical CNRE ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:4 August 2010
Referee:Prof. Dr. Armin Kurtz and Prof. Dr. Ralph Witzgall
Date of exam:10 March 2010
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Interdisciplinary Subject Network:Not selected
Keywords:renin, promoter, cAMP-response-element, cAMP, transgene, salt
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:13615
Owner only: item control page

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