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Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer

Dietmaier, Wolfgang ; Bettstetter, Marcus ; Wild, Peter J. ; Woenckhaus, Matthias ; Rümmele, Petra ; Hartmann, Arndt ; Dechant, Stefan ; Blaszyk, Hagen ; Pauer, Armin ; Klinkhammer-Schalke, Monika ; Hofstädter, Ferdinand



Abstract

Maspin, a member of the Serpin protease inhibitor family, is overexpressed in poorly differentiated colorectal tumors and more frequently found in tumors with microsatellite instability. Immunohistochemical nuclear Maspin staining is predominantly seen in tumor cells at the invasion front of such cancers, suggesting that this molecule is associated with local tumor cell infiltration and ...

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