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Mechanistic studies on monocyte migration into multicellular spheroids of breast tumor origin

Ksiazkiewicz, Magdalena (2010) Mechanistic studies on monocyte migration into multicellular spheroids of breast tumor origin. PhD, Universität Regensburg.

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Date of publication of this fulltext: 20 Apr 2010 12:24

Abstract (English)

The majority of invasive-ductal breast tumors develop a desmoplastic reaction. The most abundant stromal host cell type in desmoplastic tumors are fibroblasts. Moreover, invasive ductal breast cancer is characterized by a high MO/MAC content. These immune cells are predominantly located within the fibroblastic stroma surrounding tumor cell islets. The achieved data reveal that 3-D spheroid ...


Translation of the abstract (German)

Invasiv-duktale Mammakarzinome entwickeln häufig eine desmoplastische Reaktion. Der häufigste Zelltyp zwieschen stromal Host Zellen in desmoplastischen Tumoren sind Fibroblasten. Außerdem weisen invasiv-duktale Karzinome einen hohen Monozyten (MO)/Makrophagen(MAC) Anteil auf. Diese Immunzellen finden sich hauptsächlich im von Fibroblasten durchsetzten Stroma, das den Tumorzellen umgibt. Die hier ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:20 April 2010
Referee:Prof. Dr. Armin Kurtz
Date of exam:15 March 2010
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Keywords:monocytes, macrophages, fibroblasts, tumor associated fibroblasts, migration, CCL2, chemokines, breast cancer
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14042
Owner only: item control page


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