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Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids

Modolell, M., Andreesen, Reinhard, Pahlke, W., Brugger, U. and Munder, P. G. (1979) Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids. Cancer research 39 (11), pp. 4681-6.

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Abstract

Alkyl-lysophospholipids inhibit the growth of Meth A sarcoma cells in vitro. In contrast, murine bone marrow macrophages are not sensitive to the destructive effect of these substances. Since alkyl-lysophospholipids are antimetabolites in the synthesis of 3-sn-phosphatidylcholine, tumor cell destruction can be correlated with the disturbance of this metabolism. A decreased synthesis of ...

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Item type:Article
Date:1979
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
498095PubMed ID
Classification:
NotationType
AnimalsMESH
Cell Survival/drug effectsMESH
Lysophosphatidylcholines/pharmacologyMESH
Lysophospholipase/metabolismMESH
Macrophages/drug effectsMESH
MiceMESH
Mice, Inbred BALB CMESH
Phosphatidylcholines/metabolismMESH
Phospholipids/metabolismMESH
Sarcoma, Experimental/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:14160
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