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Differentielle Regulation des Androgenrezeptor-Promoters in hormonsensitiven und resistenten Prostatakarzinomzellen

Kopp, H. ; Masters, J. R. ; Wieland, W. ; Hofstädter, Ferdinand ; Buettner, R.


The sensitivity of prostate epithelial cells to androgens is mediated by the androgen receptor (AR). Analyses of cell lines in vitro and prostate carcinomas in vivo provide evidence that loss of AR expression parallels the loss of sensitivity to androgens. The aim of our work is to analyze the genetic control elements of the AR gene and answer the question of why these elements fail to function ...


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